A variety of treatment modalities currently exist to manage HH. Frey’s syndrome: A rare neurological disorder also called gustatory sweating. Most cases of primary hyperhidrosis are idiopathic. Primary idiopathic hyperhidrosis: Idiopathic means the disease has an unknown cause or mechanism of origin. Botulinum toxin A injections, sympathectomy, and local excision are also effective but reserved for patients that are resistant to conservative therapy.Ĭopyright © 2022, StatPearls Publishing LLC. Hyperhidrosis (HH) is a chronic disorder of excess sweat production that may have a significant adverse effect on quality of life. There are several causes of primary focal hyperhidrosis, including: 2. There are several treatment options for hyperhidrosis, including topical aluminum chloride and oral anticholinergic medications, which are sufficient in patients with mild to moderate disease. The sweating may affect the whole of your body, or it may only affect certain areas. Laboratory workup may be indicated if a secondary cause is suspected to rule out infection, hyperthyroidism, diabetes mellitus, neurologic disorder, or a medication side-effect. Hyperhidrosis is a common condition in which a person sweats excessively. The diagnosis most often is made clinically, and grading scales and tests are available to assist in determining the severity and localization. The secondary disease typically presents due to adverse effects of medications or systemic disorders, particularly neurologic. The primary disease typically presents earlier in life with more localized symptoms. Hyperhidrosis is classified as primary and secondary, and the management and treatment can significantly differ for each. Hyperhidrosis can result in emotional, psychological, social, and occupational impairment. Studies have shown the prevalence of this disorder to be approximately 3% in the United States. The acetylcholine negative feedback loop is likely impaired in these patients, which may help explain how a physiologic response can become pathologic. Eccrine glands are concentrated in areas such as the axillae, palms, soles, and face therefore, these are the areas most commonly associated with hyperhidrosis. This disorder is characterized by sweating beyond what the body uses for homeostatic temperature regulation. Hyperhidrosis is a disorder of excessive sweating due to the overstimulation of cholinergic receptors on eccrine glands.
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